Beyond these recent observations, upregulated cytokines in COVID-19 patients carrying risk alleles of APOL1 could still contribute to the development of cFSGS as a “second hit” as the expression of chemokines (e.g., CCL2 and CXCL10) and Interleukin 6 seems to be elevated within the kidney of COVID 19 patients (76). This evidence concerns the gene APOL1 and COVID-19.