Importantly, in contrast to the other plasma inflammatory markers tested in this study (Supplementary Table 1), the percentage of monocytes with inflammasome complex formation and plasma levels of the downstream cytokine IL-18 were both significantly increased in the moderate–severe group than in patients with milder symptoms (Figures 2F, G, respectively), highlighting a role for inflammasomes in COVID-19 severity. The gene discussed is IL18; the disease is COVID-19.