Moreover, the whole-blood transcriptomic data of TBM-immune reconstitution inflammatory syndrome (IRIS) patients revealed an increase in neutrophil-dependent inflammatory response with significantly more neutrophil-associated transcripts including MPO, MMP-8 and -9, CtG, lipocalin 2 (LCN2) and α-defensin (DEFA1/3/4) compared to TBM non-IRIS (134). The gene discussed is MMP8; the disease is meningeal tuberculosis.