At days 7, 17, and 24, mice implanted with tumor at day 0 were vaccinated with anti-CD40 11B6-CD40L-Doc, anti-CD40 11B6-Doc, IgG4-CD40L-Doc, and non-targeting IgG4-Doc non-covalently linked to human Coh-Cyclin D1 (Figure 11A). Here, CD40LG is linked to neoplasm.