Just as the viral RNA can innate immune-driven immunothrombosis in severe COVID-19 pneumonia, the negatively charged proteins in these adenovirus skeleton proteins may play the same role as viral RNA and form adenovirus skeleton protein-PF4 complexes (12), with this adjuvanticity likely contributing to autoantibody development and ultimately thrombosis in VITT. The gene discussed is PF4; the disease is Venous thrombosis.