TNF and infection: No significant difference in IL-6 gene expression was found in the hearts of STING-KO-infected mice when compared with C57BL6 mice (Figure 4B), while significantly lower TNF-α gene expression was observed in the hearts of STING-KO mice 13 days after infection (Supplementary Figure S1C), indicating that STING deficiency negatively impacts the expression of key genes related to protection against acute T. cruzi infection.