No significant difference in IL-6 gene expression was found in the hearts of STING-KO-infected mice when compared with C57BL6 mice (Figure 4B), while significantly lower TNF-α gene expression was observed in the hearts of STING-KO mice 13 days after infection (Supplementary Figure S1C), indicating that STING deficiency negatively impacts the expression of key genes related to protection against acute T. cruzi infection. The gene discussed is IL6; the disease is infection.