HAVCR2 and experimental autoimmune encephalomyelitis: Here using cell-based, molecular biology and in vivo approaches, we identified a new way of MHC-II regulation; that is, by suppressing CIITA expression, Tim-3 inhibits MHC-II expression in macrophages and then downregulates the presentation of autoantigen MOG to CD4+T cells, finally leading to immune tolerance in mice with experimental autoimmune encephalomyelitis.