ADAM22 and encephalitis: 1. IgG of patients with Limbic encephalitis, but not from healthy participants, prevent the binding of LGI1 to ADAM23 and ADAM22 (70). LGI1- and CASPR2 antibodies containing CSFs, of patients with autoantibody-mediated forms of encephalitis, increased the probability of glutamate release from CA3 neurons. In addition, these CSFs induced epileptiform activity at a population level following Schaffer collateral stimulation (169).