1. CASPR2 antibodies bind to hippocampal neurons and to CASPR2-transfected HEK cells, and lead to some internalization of the IgG (72). CASPR2 and LGI1 antibodies containing CSFs, of patients with autoantibody-mediated forms of encephalitis, increased the probability of glutamate release from CA3 neurons. In addition, these CSFs induced epileptiform activity at a population level following Schaffer collateral stimulation (169). The CASPR2 antibodies containing CSF was also associated with higher spontaneous firing of CA1 pyramidal neurons (169). The gene discussed is CNTNAP2; the disease is encephalitis.