Elevated levels of GluR3 antibodies, especially GluR3B peptide antibodies, were found so far in serum of about 27% of >300 of persons with severe, intractable and enigmatic epilepsy of various types [(2–5, 10, 13–16, 20, 21, 23, 24, 28, and see a partial summary in a review article entitled: "Glutamate receptor antibodies in neurological diseases" (31)]. This evidence concerns the gene GRIA3 and epilepsy.