When CD209+ DC were exposed to RA SF we observed an increase in CCR7 and CXCR3, together with an increase in the co-expression of CXCR3/CXC5/CXCR5 and CCR6/CCR7/CXCR3/CXCR4 suggesting that the joint micro-environment enhances CD209/CD14+ DC trafficking. This evidence concerns the gene CXCR3 and rheumatoid arthritis.