Hypoxia and cell death of expanding adipose tissue, activation of the nuclear factor-κB (NF-κB) and JUN N-terminal kinase (JNK) pathway, activation of interleukin-1β (IL-1β), and recruitment and activation of immune cells were all linked to the inflammatory state in T2D (Donath and Shoelson, 2011; Gianchandani et al., 2020). Here, MAPK8 is linked to type 2 diabetes mellitus.