It has been reported that PTPN6 mediated autophagy contributes to the inhibition of macrophage foam cell formation by the D3-VDR-PTPN6 axis (46), and participates in the epigenetic regulation mechanism of advanced chronic myeloid leukemia (47). The gene discussed is VDR; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.