DRD2 and pituitary tumor: In the context of pituitary neuroendocrine tumors (PitNET), DAs lead to the inhibition of hormonal secretion and tumor shrinkage in different pituitary tumor histotypes by mainly binding to the dopamine receptor type 2 (D2DR), largely expressed in lactotroph pituitary cells but also localized in other pituitary cell sub-populations including somatotroph and corticotroph cells (2).