In the last years, the cytoskeleton protein Filamin-A (FLNA), an actin-binding protein that regulates reorganization of the actin cytoskeleton by interacting with integrins, several GPCRs, ion channels and second messengers anchoring them to the actin cytoskeleton, is associated with the regulation of D2DR expression and signalling (75–77) in several cell system including pituitary tumor cells (78, 79). Here, DRD2 is linked to pituitary tumor.