These findings notwithstanding, in 2017 an effective and safe delivery of a micro-dystrophin transgene in juvenile GRMD dog model of DMD by both intravenous locoregional and systemic administration of a rAAV2/8 vector was achieved, showing long-term persistence (up to 24 months) in the absence of preventive immunosuppression (96). Here, DMD is linked to Duchenne muscular dystrophy.