Similarly, another preclinical study led on the GRMD dog model of DMD performed a 5-year follow-up of dystrophin rescue after either IM or intravenous of AAV1-U7E6/8, an antisense sequence which induces skipping of exons 6 and 8, carried by the engineered small nuclear RNA (snRNA) U7. Here, DMD is linked to Duchenne muscular dystrophy.