CX3CL1 and Anxiety: Anxiety symptoms after alcohol withdrawal occur when the peripheral inflammatory response is suppressed, while activation of the immune system in HF continues, as evidenced by elevated levels of cytokines (Il- 1 β, Il- 17) and chemokines (MIP-1a - macrophage inflammatory protein-1a, MIP-1a and CX3CL1- chemokine - C-X3-C motif, ligand 1, CX3CL1) in the striatum, an area of the brain involved in the development of addiction and serum.