IGHE and eosinophilic esophagitis: STAT6 polymorphisms on locus 12q13, previously associated with serum IgE levels (Granada et al., 2012), allergic sensitization (Bønnelykke et al., 2013), and asthma (Qian et al., 2014), have also been reported to have a major genetic association in EoE independent of sensitization (Sleiman et al., 2014) but a subsequent meta-analysis did not confirm the finding (Kottyan et al., 2021).