Glucocorticoid treatment reduces interleukin-13 transcription and the EoE transcriptome in vivo (Blanchard et al., 2007), reduces or even abolishes the eosinophilic infiltrate in 39–100% of patients (Hao et al., 2021), reduces T cell infiltration (Teitelbaum et al., 2002), downregulates mast cell associated genes (Hsu Blatman et al., 2011) and even decreases fibrosis (Aceves et al., 2010b) and restores esophageal motility (Nennstiel et al., 2016; Nakajima et al., 2017). Here, IL13 is linked to eosinophilic esophagitis.