However, about 2% of EoE transcriptional alterations do not resolve upon disease remission (Blanchard et al., 2007) with persistence of dysregulations of cadherin-like 26 (CDH26), uroplakin 1B (UPK1B), periostin (POSTN), and DSG1, all involved in epithelial homeostasis (Blanchard et al., 2007). The gene discussed is DSG1; the disease is eosinophilic esophagitis.