IL4 and eosinophilic esophagitis: Finally, in a recent study of an asthma mouse model, inhibition of CAPN by calpeptin was able to strongly reduce bronchial reactivity, bronchoalveolar lavage (BAL) fluid eosinophilia, subepithelial fibrosis and the expression of IL-4, IL-5, IL-13, TGF-β1, and ova-specific immunoglobulin E (Aich et al., 2012), suggesting its therapeutic potential in EoE.