TGFB1 and eosinophilic esophagitis: A relationship between TGF-β and EoE pathogenesis was also suggested by some inconstant genetic associations: a polymorphism (SNP C509T) in the TGFβ1 promoter on chromosome 19q13 was associated with an increase of TGFβ1 and tryptase and with increased remodeling, especially in the presence of concurrent food sensitization and steroid unresponsiveness (Aceves et al., 2010b; Rawson et al., 2015; Duong et al., 2020).