CRLF2 and eosinophilic esophagitis: Moreover, a single nucleotide variation (rs36133495) in the cytokine receptor-like factor 2 (CRLF2) gene, that codes for the receptor of TSLP and is located on the pseudoautosomal region of the sex chromosomes, was found to be associated to EoE in males and is thus the first molecular mechanism that associate EoE to its male predominance (Sherrill and Rothenberg, 2011; Holvoet et al., 2016).