Higher levels of CAPN14 expression, such as seen in active EoE (Sleiman et al., 2014; Kottyan et al., 2021), are associated with the downregulation of DSG1, FLG, and zonulin, all involved in epithelial barrier function (Sleiman et al., 2014). The gene discussed is DSG1; the disease is eosinophilic esophagitis.