TGFB1 and eosinophilic esophagitis: Thiazolidinediones rosiglitazone and pioglitazone, two PPARγ agonists, significantly inhibited TGF-β1-induced mRNA expression of several remodeling-related genes in vitro in EoE esophageal fibroblasts with a dose-dependent effect, disrupting TGF-ß-Smad signal transduction (Nhu et al., 2020).