We have previously shown decreased basal levels of MSCs-specific CD90 marker and intracellular adhesion molecule (ICAM)-1 on ASCs of SLE and SSc patients, some changes in the secretory activity of these cells that may modify their biological functions, but their normal capability to regulate the expression of activation markers on allogeneic T cells (Kuca-Warnawin et al., 2019, 2020). The gene discussed is THY1; the disease is systemic lupus erythematosus.