Besides, both cytokines contribute to disease pathology, IL-10 mostly via supporting hyperactivity of B cells and autoantibody production in SLE (Peng et al., 2013), while TGFβ is a potent inducer of fibrosis in SSc (Brown and O’Reilly, 2018), having a more complex role. The gene discussed is TGFB1; the disease is systemic sclerosis.