In contrast to kynurenines and PGE2, the concentration of IL-10 did not change or even decrease in the co-cultures of ASCs with purified CD4+ T cell and PBMCs, respectively, and there was no difference between co-cultures containing HD/ASCs, SLE/ASCs, and SSc/ASCs (Figures 6A,B). This evidence concerns the gene IL10 and systemic sclerosis.