In the co-cultures of ASCs with purified CD4+ T cells, the production of kynurenines and PGE2 was significantly higher in the presence of ASCs from SLE and SSc patients than ASCs from healthy donors (Figures 5B,D), but it was similar in the co-cultures of ASCs with PBMCs (Figures 5A,C). This evidence concerns the gene CD4 and systemic sclerosis.