CD4 and Huntington disease: In the co-cultures preventing (transwell, T-W) direct PBMCs and ASCs contact, untreated and, to a lesser extent, cytokine-licensed HD/ASCs reduced proliferation of CD4+ and CD8+ T cells (Figures 3A,B,D–F, respectively) more strongly than in co-cultures allowing cell-to-cell contact (C-C).