ASCs of patients exerted similar inhibitory effects as HD/ASCs (Figures 1A,B,D–F, 2A–C), except weaker, but statistically significant, diminution of CD4+ T-cell RI by ASCsTI of SLE and SSc patients in PBMCs + ASCs co-cultures (Figure 1C). This evidence concerns the gene CD4 and systemic lupus erythematosus.