NOS3 and hepatocellular carcinoma: Later, NF-κβ may be over expressed due to activation of eNOS/iNOS at the HCC site, and phosphorylation of NF-κβ may be taken place in the presence of AKT enzymes which results in the conversion of inactivated NF-κβ to its active form (Bonavida and Garban, 2015).