We found that a short course of systemic GC decreased the expression of coagulation factor (F13A1) and inhibitors of fibrinolysis (SERPINE1 and SERPINB2), and increased the expression of fibrinolytic genes (PLG and PLAT) in the Responder group; therefore, GC could alleviate fibrin deposition in nasal polyps. Here, PLAT is linked to Nasal polyposis.