Prediagnostic cases below the cutoff value for CA19-9, in combination with LRG1 and TIMP1, was identified as useful for the early detection of pancreatic cancer (Choi et al., 2021; Fahrmann et al., 2021); also, these results were strongly supported in a pancreatic cancer animal model (Fukamachi et al., 2019; Harlid, Gunter, and Van Guelpen 2021; Lee et al., 2021). This evidence concerns the gene TIMP1 and pancreatic neoplasm.