GPBAR1 and cholestasis: However, due to the wide expression of GPBAR1 in various cells, GPBAR1 also has potential hazards and can promote tumour cell proliferation, and effective inhibition of GPBAR1 may inhibit tumour cell proliferation and metastasis; however, in cholestatic liver disease, because patients with cholestasis can develop CCA at a later stage, the characteristics of GPBAR1 become intriguing.