The association between GPBAR1 and NLRP3 has also been demonstrated, but most studies have mainly confirmed the effect of GPBAR1 on the NLRP3 inflammasome in the context of neuroinflammation, colitis, pancreatitis and nonalcoholic steatohepatitis (NASH) (Li B. et al., 2018; Chen et al., 2019; Shi et al., 2020; Liang et al., 2021). The gene discussed is NLRP3; the disease is metabolic dysfunction-associated steatohepatitis.