CXCR3/CXCL10 axis contributes to the recruitment of inflammatory cells and the production of cytokines in RA progression (Lee et al., 2017), chronic prostatitis (Hua et al., 2021), inflammatory bowel disease (Zhao et al., 2017), etc. In addtion to its traditional functions in inflammation and immunity as we known, the potential role of CXCR3 in chronic dermatitis on itch sensation has attracted growing attention in recent years. This evidence concerns the gene CXCL10 and rheumatoid arthritis.