CXCR3 and Dry skin: Similarly, though paeonol significantly impaired the scratching frequency in AEW-induced C57BL/6J mice, it was almost ineffective in Cxcr3−/− mice stimulated by AEW (Figures 7B–D), demonstrating that spinal CXCR3 was indispensable for the anti-pruritic activity of paeonol in AEW-induced dry skin.