Administration of a CXCR3 antagonist alleviated the itch behavior in dry skin model mice stimulated with acetone and diethyl ether followed by water (AEW), and Cxcr3−/− mice showed attenuated scratching in chronic itch models of dry skin and ACD (Qu et al., 2015; Qu et al., 2017; Jing et al., 2018). Here, CXCR3 is linked to granular corneal dystrophy type II.