STAT3 and neoplasm: We also screened the effects of TA on several other signaling pathways important in tumor growth and progression including the oncogenic transcription factors STAT3 and MYC, the mitogen-activated serine/threonine kinases S6 protein kinase (S6K), ERK, and AKT, and the levels and phosphorylation status of proteins that control cell cycle progression including Cyclin D1, Cyclin B1, and cleavage of PARP and Caspase 3 as markers of apoptotic cell death.