RPS6KB1 and breast neoplasm: Figure 6D summarizes the common biochemical responses to TA and DDAs that are hypothesized to mediate in part, the anticancer activity of these compounds. The results in Figure 4 examining TA/DDA mono- and combination regimens against breast tumors indicate that TA suppresses S6K1 phosphorylation on Thr389 in tumors in vivo.