Previous work indicated that Plasmin cleaves the extracellular domain of the transmembrane protein CUB Domain-Containing Protein 1 (CDCP1) to produce a truncated protein that exhibits differential protein-protein interactions and signaling functions compared with the full-length protein, suggesting that cleaved CDCP1 (cCDCP1) may contribute to tumor growth and progression (Casar et al., 2014; Law et al., 2016; Wright et al., 2016). This evidence concerns the gene CDCP1 and neoplasm.