We are not the first ones to report sex-specific differences in Fat-1 mice; a recent study investigating the role of elevated tissue levels of ω-3 fatty acids in obesity-associated post-traumatic osteoarthritis also reported sex-specific differences in Fat-1 transgenic mice (Kimmerling et al., 2020). This evidence concerns the gene FAT1 and obesity due to melanocortin 4 receptor deficiency.