The alkaloid regulated glucose uptake and utilization and reduced insulin resistance through upregulating the expression of insulin receptor substrate 2 (IRS2), phosphoinositide-3-kinase regulatory subunit 1 (PI3KR1), phosphorylated protein kinase B (p-AKT), phospho-AMP-activated protein kinase (p-AMPK) and glucose transporter 4/1/2 (GLUT4/1/2) (Zhu et al., 2018). This evidence concerns the gene IRS2 and Insulin resistance.