The alkaloid effectively downregulated TNIK, p-TNIK, β-catenin, F-actin and N-cadherin expression levels, and upregulated GSK-3β and E-cadherin in in vitro (MDA-MB-231 cells and MCF-7 cells) and in vivo models (Orthotopic 4T1 tumour bearing mouse) (Sun et al., 2019). The gene discussed is GSK3B; the disease is neoplasm.