INS and Hyperglycemia: Jatrorrhizine displayed anti-diabetic activity in vitro (RINm5F cells and HepG2 cells) and in vivo (glucose-loaded rats and hyperlipidemic mice) via promoting insulin secretion, improving glucose tolerance and insulin sensitivity and inhibiting hepatic gluconeogenesis, thus improve postprandial hyperglycemia (Patel and Mishra, 2011; Chen et al., 2012; Yang et al., 2016; Li et al., 2020).