AKT1 and thyroid gland carcinoma: Besides, jatrorrhizine-Platinum(II) complex promoted DNA damage of thyroid cancer SW1736 and BHP7-13 cells via increasing pH2AX protein (DNA damage protein) and decreasing DNA repair protein KU70, KU80 and RAD51, while activated apoptosis by upregulating ROS and cleaved caspase-3, and downregulating PI3K/AKT/mTOR pathway (pS6, p-ERK1/2, p-4E-BP1, and p-AKT levels) (Lu et al., 2020).