The present study revealed that Caveolin-1, alone with p-Src, increased in ischemic stroke mouse brain tissue upon delayed treatment with tPA, consistent with the result from others (Chen S. et al., 2018), which was abrogated by addition of QSYQ, suggesting Src/Caveolin-1 as one of the targets for QSYQ to act. Here, CAV1 is linked to ischemic stroke.