In both tumor models, 17-DMAG inhibited not only AKT1 and ERK phosphorylation but also proliferative markers such as CyclinD1 and induced cleaved Caspase3 expression, indicating a similar effect on HSP90 regulation of the AKT1/ERK pathway in vitro (Figures 8A–C). The gene discussed is HSP90AB1; the disease is neoplasm.