STGPT repressed N-nitrosodiethylamine-induced murine hepatocellular carcinoma progression by inhibiting HIF-1α via the interference with the AKT-AMPKα-mTOR axis and the interruption of IKKβ, P38α, and ERK1/2 signals as well (Supplementary Material). Here, HIF1A is linked to hepatocellular carcinoma.