This is in line with our current understanding that the entorhinal cortex is among the earliest regions of tau accumulation where tau seems to increase with age even before amyloid starts deposing (Maass et al., 2018), whereas other MTL and more posterior regions are affected once amyloid pathology induces the spread of tau into the neocortex (Sanchez et al., 2021). The gene discussed is MAPT; the disease is amyloidosis.