MAPT and Alzheimer disease: To date, while the complexity of neurodegeneration continues to be explored and recognized, AD has been characterized in part by excessive extracellular beta-amyloid (Aβ) plaque accumulation, the presence of intracellular tau-containing neurofibrillary tangles, and neuroinflammation in the brain (Erika et al., 2018; Rai et al., 2020; Knopman et al., 2021; Singh et al., 2021).