PTPA and Huntington disease: Activation of the D2 receptors (and not D1 receptors) can activate PP2A and inhibit the production of inflammatory cytokines and chemokines (Han et al., 2017); because PP2A can dephosphorylate Ser940 on KCC2 (Lee, 2009), it is possible that enhanced dopamine signaling early in HD (Chen et al., 2013) leads to an early PP2A-mediated reduction of KCC2 activity specifically on D2-MSNs.