Despite the various interactome studies linking Htt and KCC2 (Shirasaki et al., 2012; Kalathur et al., 2015; Mahadevan et al., 2017), the authors were the first to validate the interaction between KCC2 and Htt protein in a HD mouse model; they performed co-immunoprecipitation assays in the R6/2 model. Here, HTT is linked to Huntington disease.