Impaired GABAergic signaling directly contributes to the cognitive and motor deficits associated with HD, and results in part from alterations in two cation-chloride cotransporters (CCCs): Na+-K+-Cl– co-transporter-1 (NKCC1) and K+-Cl– co-transporter-2 (KCC2). The gene discussed is SLC12A2; the disease is Huntington disease.