Regardless, a depolarizing shift in EGABA may not necessitate aggregate formation, as the reversal of GABA polarity in HD is primarily due increased NKCC1 activity compared to decreased KCC2 function (Dargaei et al., 2018), despite there being no known interaction between NKCC1 and (m)Htt. The gene discussed is HTT; the disease is Huntington disease.