SCAMP5 and autism spectrum disorder: Since both NHE6 and SCAMP5 are associated with autism spectrum disorder (ASDs; Morrow et al., 2008; Castermans et al., 2010; Kondapalli et al., 2014; Schwede et al., 2014), regulation of vesicular glutamate content by NHE6 and SCAMP5 may be implicated in the pathogenesis of ASDs.