While RIBEYE is well known for its role in glutamate release from PR and BC terminals, the role of the shorter CTBP2 isoform has not been extensively studied in the eye but rather from cancer and stem cell studies (Chew and Gallo, 2009; Kim et al., 2017; Chen et al., 2020; He et al., 2021). The gene discussed is CTBP2; the disease is cancer.