In addition, our study showed that the mRNA expression level of GPR39, IL-6, IL-33, and thymic stromal lymphopoietin (TSLP) in the skin of dry skin mouse model were significantly upregulated compared with that of the control group (t8 = 6.055, P = 0.0003; t8 = 5.267, P = 0.0008; t8 = 6.182, P = 0.0003; t8 = 2.317, P = 0.0492; Figure 9D). This evidence concerns the gene GPR39 and Dry skin.