TRPA1 was well-known for mediating histamine-independent itch, including mas-related G protein-coupled receptors (Mrgprs)-mediated itch (Wilson et al., 2011), oxidative stress-induced itch (Liu and Ji, 2012; Zhou et al., 2017), endothelin 1 (ET-1)-induced itch (Magnusdottir et al., 2020), miRNA-711-mediated cancer itch (Han et al., 2018), and 5-HT7 receptor-mediated serotonergic itch (Morita et al., 2015). The gene discussed is EDN1; the disease is cancer.