In models of subarachnoid hemorrhage (Xie et al., 2017), multiple sclerosis (Voortman et al., 2017), and stroke (Yu et al., 2017), NTN-1 has been shown to have a protective effect on the BBB and to improve neurocognitive function, which was also noted in our model. This evidence concerns the gene NTN1 and multiple sclerosis.