APOE and Alzheimer disease: RNAseq in mouse models of AD has been used to identify neuroprotective “disease-associated microglia” (DAM) as described by Keren-Shaul et al. (2017) and the “microglial neurodegenerative phenotype” (MGnD) (Krasemann et al., 2017)—both of which are characterised by TREM2 activation and associated with increased APOE expression.