PSEN1 and Alzheimer disease: Other Aβ plaque types include subpial bands (Thal et al., 2000), cotton-wool plaques which feature prominently in PSEN1 (also PS1; encoding presenilin 1) familial AD (Tabira et al., 2002), lake-like patches in the presubiculum (Wisniewski et al., 1998), and the recently described coarse-grained plaques in early onset AD (Boon et al., 2020).