SNAP25 and Alzheimer disease: Finally, a pre-print of one study which used fluorescence-activated cell sorting of NFT-bearing and NFT-free soma from Braak stage VI AD prefrontal cortex showed NFT-bearing neurons were associated with an upregulation of genes involved in synaptic transmission, including a core set of 63 genes seen across different neuronal subtypes that were enriched for synaptic vesicle cycling (e.g., SNAP25; SYT1 encoding synaptotagmin 1) and transsynaptic signalling (e.g., NTRK2 encoding the BDNF receptor TrkB) (Otero-Garcia et al., 2020).