TARDBP and amyotrophic lateral sclerosis: They have, in addition, been widely used to study ALS-like TDP-43 neurotoxicity (Yang et al., 2010; Colombrita et al., 2012; Lu et al., 2012; Smethurst et al., 2016; Moujalled et al., 2017; Tian et al., 2017; Chen T. et al., 2018; Maurel et al., 2018; Salvatori et al., 2018; Hicks et al., 2020).