Moreover, the pathology of brains from Grn–/– mice differs from that of human FTD-GRN, and appears closer to NCL (Ahmed et al., 2010), while GRN+/− mice, that genocopy human FTD-GRN, show only mild phenotypes that are not fully representative of the human disease (Filiano et al., 2013). Here, GRN is linked to frontotemporal dementia.