The rodent models of colitis that have previously been used to study vagus nerve and α7 nAChR-mediated regulation of disease severity are by many considered more relevant to ulcerative colitis than to Crohn’s disease (Snoek et al., 2010; Galitovskiy et al., 2011; Ghia et al., 2011; Ji et al., 2014). The gene discussed is CHRNA7; the disease is colitis.