TOP1 and neoplasm: It is reported that hexadecanoic acid exhibited the cytotoxic effect by selectively inhibiting DNA topoisomerase I in the tumor cells [15].Docking study confirmed the interaction between hexadecanoic acid and DNA topoisomerase I. Thus, the presence of hexadecanoic acid and ethyl ester (ethyl palmitate) in the diethyl ether fraction may be responsible for preventing cell proliferation.