Betulin has the potential to selectively inhibit the activity of DNA topoisomerasesII, without any influence on DNA topoisomerases I. Betulinic acid, a derivative of botulin, is a wellknown inhibitor of other cancerous tumors, including human colon carcinoma and human prostate adenocarcinoma [17]. The gene discussed is TOP1; the disease is prostate adenocarcinoma.