MTOR and non-small cell lung carcinoma: EIF2S1 is a subunit of the translation initiation factor EIF2 complex.30,31 Interestingly, mouse embryonic fibroblasts with the Eif2s1 mutation grew 50% slower and showed reduced Pdk1-Akt-mTOR signaling compared to wild-type cells.31 We hypothesized that high levels of LCETRL4 may stabilize EIF2S1, reinforce phosphorylation of PDK1 and, thus, promote activation of the AKT signaling in NSCLC.