Our study also demonstrated that increased expression of TDP43 controlled by lncRNA LCETRL3 could stabilize the NOTCH1 mRNA, elevate NOTCH1 expression, downregulate PTEN expression and activate AKT in NSCLC cells, which thereby accelerating tumor growth and reduce EGFR-TKIs efficiency. The gene discussed is PTEN; the disease is non-small cell lung carcinoma.