Long noncoding RNAs (lncRNAs) are a group of ncRNAs with a length greater than 200nt, which play a vital part in human cancers including NSCLC.13–15 Accumulating evidences elucidated that multiple lncRNAs contributed to the development of EGFR-TKIs resistance in NSCLC.16–21 For instance, lncRNA H19 conferred to EGFR-TKIs resistance via interacting and upregulating PKM2 and increasing levels of AKT phosphorylation in NSCLC.18 However, the role of lncRNAs transcribed from the 4q12 locus in NSCLC development and progression remains to be explored. The gene discussed is EGFR; the disease is cancer.