TARDBP and melanoma: We revealed that lncRNA LCETRL3 can interact with TDP43 protein and suppress degradation of TDP43, an RNA-binding protein that participates in multiple steps of RNA metabolism, including transcription, splicing, and transport of mRNA, as well as miRNA metabolism.24 TDP43 has been shown to promote growth and metastasis of NSCLC, triple-negative breast cancer, neuroblastoma, hepatocellular carcinoma and melanoma.35–40 Consistently, we found that TDP43 was significantly upregulated in NSCLC tissues.