EIF2S1 is a subunit of the translation initiation factor EIF2 complex.30,31 Interestingly, mouse embryonic fibroblasts with the Eif2s1 mutation grew 50% slower and showed reduced Pdk1-Akt-mTOR signaling compared to wild-type cells.31 We hypothesized that high levels of LCETRL4 may stabilize EIF2S1, reinforce phosphorylation of PDK1 and, thus, promote activation of the AKT signaling in NSCLC. This evidence concerns the gene PDK1 and non-small cell lung carcinoma.