The chromosome 4q12 is the first GWAS-identified locus associated with PFS of advanced NSCLC patients treated with EGFR-TKIs.7 For protein-coding genes at 4q12, NMU which encodes a GPCR ligand was known to be involved in NSCLC progression.32,33 However, the biological significance of the noncoding transcripts at 4q12 remains elusive in NSCLC. This evidence concerns the gene EGFR and non-small cell lung carcinoma.