The association between organ carcinogenesis and AMIGO2 expression has been reported in various types of cancer, including gastric cancer [13, 14], pancreatic cancer [20], colorectal cancer [11, 19], breast cancer [12], ovarian cancer [17], endometrial cancer [21], melanoma [15, 16, 40], and pituitary neuroendocrine tumors [18]. Here, AMIGO2 is linked to melanoma.