More generally, genetic aberrations of many of the differentially methylated genes in our study, i.e., TRIO, NRXN2, SYN2, CACNA1E, DNM1 and RAB11B, have been associated with movement disorders, cognitive and visual impairments and brain abnormalities (e.g., atrophy, white matter apoplasia) [69]. Here, CACNA1E is linked to Visual impairment.