TGFB1 and myeloid sarcoma: We found DNA methylation changes at genes involved in cellular motility, cytoskeleton rearrangement, cell-to-cell and intracellular signaling, such as Wnt and TGF-β signaling, neuromodulation and neuroinflammation, among others, a fraction of these genes were previously shown to be dysregulated in the brain of MS patients.