These DMP-genes reported as differentially expressed both in the bulk NAWM and in glial cells from MS lesions reflect alterations in oligodendrocytes (DYSF, RBFOX1, PPP1R12B, KIF5C, PER3 genes), microglia (GPX1, HIVEP3, CDCP1, HERPUD1, HLA-DPA1, FYB, SCIN genes), astrocytes (PRDM16, GLI3, WIF1, SLIT3 genes) or in multiple glial cell types (KCNMA1, NTM, NRP1, CDH4, TRIO genes) in MS compared to NNC individuals (Supplementary Table 2). Here, HIVEP3 is linked to myeloid sarcoma.