GSEA enrichment analysis indicated that ADAM12 might be associated with the cytokine-cytokine receptor interaction pathway, the ECM receptor interaction pathway, FC-γ-R-mediated phagocytosis, cytokines, ECM receptors, and the FC-γ-R, which are common immune regulatory pathways Previous studies also indicated that ADAM12 might play a role in lung adenocarcinoma, and pancreatic cancer through immune pathways. Here, ADAM12 is linked to lung adenocarcinoma.