Similar to these results, several human autopsy reports have documented the presence of SARS-CoV-2 RNA in brain tissues.26,27 Coincidently, a previous study on SARS-CoV-2-infected K18-hACE2 mice also reported SARS-CoV-2 infection of the nasal turbinate, eyes, and olfactory bulb, indicating that the virus may enter the brain by the nasal route after intranasal infection.20 Our observations imply that the lamina propria underlying the olfactory epithelium may play an important role in the infection of the olfactory nerves, as an infection route from the nose to the brain in K18-hACE2 Tg mice. Here, KRT18 is linked to infection.