CD8A and neoplasm: It is noteworthy that in the AbsCryo tumors, there was a significant increase in mean (SD) normalized fluorescence for CD8α (15.7 [12.1]; p = 0.020] and the CD8 CTL activation marker granzyme B (4.8 [3.6]; p = 0.048) compared with TBaseline (5.2 [4.7] and 2.4 [0.09], respectively), indicating increased activated CTLs in the tumor (Fig. 4).