CD4 and neoplasm: When CD4+ T cells from OTII TCR transgenic mice were activated in vitro and injected intravenously into C57BL/6 mice on day 9 after transplantation of E0771-control-I-Ab/OVA or 3LL-control-I-Ab/OVA, tumor growth was markedly suppressed (Fig. 4D and E).