In the 71 patients with baseline Hematotox score ≥2 exposed at day 90, incidence at day 90 of grade 3-4 neutropenia, grade 3-4 anemia, and grade 3-4 thrombocytopenia was 9 (12.7%), 1 (1.4%) and 5 (7.0%) respectively, with no difference between the G-CSF groups (p = 1.00, p = 0.27, p = 0.12). This evidence concerns the gene CSF3 and Decreased total neutrophil count.