Artificial inactivation of GM-CSF, via antibodies or genetic technologies, showed not to impact on anti-tumor capacity and proliferation of CAR-T in vitro, and to reduce secretion of CRS biomarkers depending from macrophages, including monocyte chemoattractant protein 1 (MCP-1), interleukin (IL) 6, and IL-8 [13, 14]. Here, CCL2 is linked to neoplasm.