The actinomycin D assay also showed that knockdown of YTHDF2 could decelerate the mRNA decay of IFIT2 (Fig. 7I), and METTL3 knockdown has no significant effect on decelerating the mRNA decay of IFIT2 in ICC cells with YTHDF2 knockdown (Supplementary Fig. 5). This evidence concerns the gene YTHDF2 and intrahepatic cholangiocarcinoma.