Tnfrsf1a (Figures 1F and S2D), a MS susceptibility gene encoding for TNF receptor superfamily member 1A (De Jager et al., 2009), had increased CA at the promoter in both MOL1/2-EAE and MOL5/6-EAE populations, which also presented increased gene expression in EAE scRNA-seq data (Falcão et al., 2019) (Figure S2E). This evidence concerns the gene TNFRSF1A and myeloid sarcoma.