Thus, TFs as SOX8, implicated in OLG development (Stolt et al., 2004) and MS susceptibility (International Multiple Sclerosis Genetics Consortium, 2019), might work in concert with TFs other than the ones they usually cooperate with during development and homeostasis, in order to regulate immune gene transcription in OLG in EAE/MS. The gene discussed is SOX8; the disease is multiple sclerosis.