Besides, Lenalidomide, a 4-amino-glutamyl analogue of thalidomide that acts as an angiogenesis inhibitor, showed the capability to intensify the HER2-CAR T cells cytotoxicity against human breast tumor MDA-MB-453 by induction higher levels of the cytokine secretion but not affecting their proliferation [132]. Here, ERBB2 is linked to breast neoplasm.