A study of the tumor samples from 175 patients with pulmonary adenocarcinomas for examination of the existence of HER2 amplification and mutation and HER2 protein overexpression revealed that HER2 amplification was seen in 3%, HER2 mutation was detected in 4%, and finally, HER2 overexpression was found about 14% [78]. Here, ERBB2 is linked to neoplasm.