AKT1 and early-onset autosomal dominant Alzheimer disease: Several neurodegenerative disease pathways were significantly enriched (Huntington disease (mmu05016), Parkinson disease (mmu05012) and Alzheimer disease (mmu05010)), as well ageing-associated pathways such as FoxO signalling (mmu04068), HIF-1 signalling pathway (mmu04066), PI3K-Akt signalling (mmu04151) and oxidative phosphorylation (mmu00190) (Fig. 4B).