It was then not surprising that IPA outputs revealed upstream regulators and master regulators that too have been strongly implicated in neurodegenerative disease such as PPARG coactivator 1 alpha (PPARGC1A) [21, 51, 73] and the mitochondrial uncoupling protein Thermogenin (UCP1) [19, 44, 53]. The gene discussed is PPARGC1A; the disease is neurodegenerative disease.